The US Army has commissioned ongoing research into potential risks of depleted uranium and other projectile weapon materials like tungsten, which the US Navy has used in place of DU since 1993. Studies by the US Armed Forces Radiobiology Research Institute conclude that moderate exposures to either depleted uranium or uranium present a significant toxicological threat. One particular subgroup of veterans which may be at higher risk comprises those who have internally retained fragments of DU from shrapnel wounds. A laboratory study on rats produced by the Armed Forces Radiobiology Research Institute showed that, after a study period of 6 months, rats treated with depleted uranium coming from implanted pellets, comparable to the average levels in the urine of Desert Storm veterans with retained DU fragments, had developed a significant tendency to lose weight with respect to the control group. Substantial amounts of uranium were accumulating in their brains and central nervous systems, and showed a significant reduction of neuronal activity in the hippocampus in response to external stimuli. The conclusions of the study show that brain damage from chronic uranium intoxication is possible at lower doses than previously thought. Results from computer-based neurocognitive tests performed in 1997 showed an association between uranium in the urine and "problematic performance on automated tests assessing performance efficiency and accuracy." D.E. McClain, A.C.Miller and J.F.Kalinich (June 2005). Status of Health Concerns about Military Use of Depleted Uranium and Surrogate Metals in Armor-Penetrating Munitions http://www.afrri.usuhs.mil/www/outreach/pdf/mcclain_NATO_2005.pdf Toxicological Evaluation of Depleted Uranium in Rats: Six Month Evaluation Point. Armed Forces Radiobiology Research Institute. AFRRI Special Publication 98-1. http://www.afrri.usuhs.mil/www/outreach/pdf/pellmar.pdf "Military medical aspects of depleted uranium munitions". ADF Health (Australian Defence Forces) http://www.defence.gov.au/health/infocentre/journals/ADFHJ_sep02/ADFHealth_3_2_50-57.pdf
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